PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4114)
Related Products (4114)
-
PROTAC Linkers Isoform Comparison
-
Br-PEG4-C2-Boc
0 ImagesBr-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
-
7-Octynoic acid
0 Images7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
NH2-PEG2-CH2-Boc
0 ImagesCat. No.: HY-42427CAS No.: 1948273-09-3
-
H-Glu-OtBu
0 ImagesH-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
-
1-Cbz-azetidine-3-carboxylic acid
0 Images1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]-
Boc-NH-PEG4
0 ImagesSynonyms: PROTAC Linker 12
-
Bromo-PEG3-C2-acid
0 ImagesCat. No.: HY-W039168CAS No.: 782475-35-8
-
Fmoc-NH-PEG2-C2-NH2 hydrochloride
0 ImagesCat. No.: HY-W021402CAS No.: 868599-73-9
-
4-(Aminoethyl)-1-N-Boc-piperidine
0 ImagesCat. No.: HY-40335CAS No.: 146093-46-1
![tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate](https://file.medchemexpress.com/product_pic/hy-20239.gif "Click to View tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate Product Detail")
